We know that
1] Tsunade is a surviving member’s in the clan. She was Hashirama’s grand-daughter Also, her grandmother is an Uzumaki Mito.
2] Some of the previous member’s (currently dead) , Tsunade’s brother (Nawaki), Hashirama Senju, Tobirama Senju, Butsuma Senju And Itama Senju.
3] We know that Senju clan are descendant’s of the second son Hagoromo Ōtsutsuki Sage of Six Paths. This son was supposed to have the body of the sage inherit father’s willpower and physical energy. This son also believed in tha love means peace. We All know that The Uzumaki clan is a distant And relative’s to Senju. Therefore it is natural to conclude tha Uzumaki clan is also a descendant of the second son Hagoromo Ōtsutsuki given their affinity to be excellent jinchuuriki to the all powerful Nine Tail’s.
4] Senju is summarization of “Senjutsu” which means “1000 techniques”. It is fair to assume that this clan did not mastered one particular technique’s but had masterd over several technique’s spanning ninjutsu, genjutsu, taijutsu.
5] Their bloodline limited technique is Mokuton ninjutsu and the only known user is Hashirama. There are others who have manage to unified his cells and use them of course.